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Dr. Mario is very similar to his original, but is overall slightly stronger. Dr. Mario can edgeguard effectively using his Back Aerial, Super Sheet, and his slow-moving projectile, Megavitamins. A good aerial game, wavedash, and SHFFL also contribute to his overall strength as a character. He can also has a chaingrab against some characters, and also possesses a Down Throw that can very effectively combo into his Forward Aerial for a KO. His Back Throw can be effectively used to set up gimp kills due to its powerful knockback.
Dr. Mario's biggest weakness is his recovery. His Super Jump Punch is predictable and easily edgeguarded, while his recovery on the whole is also fairly short.